Medication response, cannabis sensitivity, and psychedelic pathways.....guided by your biology

What if your body responds differently than expected?

To medications.
To cannabis.
To CBD or THC.
To ketamine.
To psychedelics.
To compounds that affect mood, cognition, stress, metabolism, and perception.

Some people feel almost nothing from a standard dose.
Others feel too much.
Some experience side effects quickly.
Some metabolize certain compounds slowly.
Some feel calm. Others feel anxious, sedated, overstimulated, or mentally foggy.

And often, they are left wondering:

“Is this normal?”
“Why did this affect me so differently?”
“Why did that medication work for someone else, but not for me?”
“What should I tell my doctor before trying something new?”

The answer may begin with your genetics.

The Medicine Match™ Genetic Test kit helps you understand genetic patterns related to medication metabolism, cannabis sensitivity, cannabinoid processing, stress response, cognitive effects, dependence risk, THC-related psychosis risk, ketamine response, and psychedelic metabolism.

Not to tell you what to take.
Not to recommend a medication or substance.
Not to replace medical guidance.

But to give you structured genetic information you can use in conversations with licensed healthcare providers.

Because when it comes to compounds that affect the body and brain, guessing is not a strategy.

Awareness is.

The Medicine Match™ test includes a pharmacogenomics report designed to help you and your provider better understand genetic factors related to medication response.

This report includes:

• My Medications
• Medication Summary
• Medications by therapeutic class
• Pharmacogenomics information related to drug metabolism
• A PGx Info Card with an abbreviated genetic summary to share with your doctor before being prescribed medications

This section gives you a clearer way to talk with your provider about your medication history, possible metabolism patterns, and questions that may be worth discussing before starting, stopping, or changing prescriptions.

Cannabis Genetics

Sensitivity. Endocannabinoid tone. Individual response.

Cannabis affects people differently.

For one person, CBD may feel calming.
For another, it may feel subtle or barely noticeable.

For one person, THC may feel relaxing.
For another, it may feel disorienting, sedating, anxiety-provoking, or mentally overwhelming.

These differences can be influenced by genetics.

This section explores:

• 2 SNPs related to cannabis genetics
• Endocannabinoid level tendencies
• Sensitivity to CBD
• Sensitivity to THC

Cannabis & Stress

Nervous system response. Stress adaptation. Emotional sensitivity.

Cannabis does not exist in isolation.

It interacts with your nervous system, stress response, mood state, and emotional baseline.

Some people feel more relaxed.
Some feel more introspective.
Some feel more anxious.
Some find that stress changes their response dramatically.

This section explores:

• 6 SNPs related to cannabis and stress
• Stress adaptation pathways
• Genetic tendencies that may influence emotional response
• How stress biology may interact with cannabis sensitivity

Understanding this section can help provide context for why cannabis may feel different depending on your nervous system state.

Subjective Response to Cannabis

Mood. Sedation. Appetite. Personal experience.

Cannabis response is deeply subjective.

It can affect mood, appetite, energy, sleepiness, motivation, and perception in very different ways depending on the person.

This section explores:

• 5 SNPs related to subjective cannabis response
• Cannabis effects on mood
• Sedative effects from THC
• CBD effects on appetite
• THC effects on appetite

For some people, cannabis may feel emotionally soothing.

For others, it may feel dulling, stimulating, appetite-changing, or unpredictable.

This report helps you better understand genetic patterns that may shape your experience.

Not to encourage use. But to bring clarity to response.

Cannabinoid Metabolism

THC processing. CBD processing. Duration and intensity.

Two people can consume the same compound and have completely different experiences.

Metabolism matters.

This section explores:

• 19 SNPs related to cannabinoid metabolism
• THC metabolism and rate
• CBD metabolism and rate
• Genetic pathways involved in cannabinoid processing
• Potential differences in duration, intensity, and clearance

When you understand cannabinoid metabolism, you gain context for why effects may feel stronger, weaker, faster, slower, shorter, or longer than expected.

This can be especially useful information to discuss with a qualified provider in settings where cannabinoid use is medically relevant or legally permitted.

Cannabis & Cognitive Function

Focus. Processing. Mental clarity.

Some people feel mentally clear with cannabis.

Others experience brain fog, slowed thinking, distractibility, or difficulty focusing.

This section explores:

• 4 SNPs related to cannabis and cognitive function
• THC effects on cognition
• Genetic patterns related to attention and mental processing under THC exposure

This information can help you better understand why cannabis may affect your thinking differently than it affects someone else.

Cannabis Dependence Risk

Reward pathways. Habit patterns. Self-awareness.

Any substance that affects mood, reward, stress, or relief can interact with habit-forming pathways.

Some people may be more genetically vulnerable to relying on cannabis for regulation, sleep, stress relief, or emotional escape.

This section explores:

• 5 SNPs related to cannabis dependence
• Cannabis dependence risk
• Reward pathway tendencies
• Genetic context for habit formation and reinforcement

This information is not a label. It is not a diagnosis.

It is a tool for self-awareness. Especially for individuals who want to understand their relationship with cannabis more honestly and proactively.

THC Psychosis Risk

Perception. Sensitivity. Psychological safety.

THC can affect perception, thought patterns, emotional intensity, and psychological state.

For some individuals, certain genetic patterns may be associated with heightened sensitivity to THC-related perceptual or psychological effects.

This section explores:

• 5 SNPs related to THC psychosis risk
• THC psychosis risk
• THC psychedelic effect
• Genetic patterns related to heightened sensitivity or altered perception

This section is especially important for informed conversations with qualified professionals.

Psychedelics Panel

Response. Breakdown. Neurotransmitter pathways.

Psychedelic response can vary widely.

Some people report emotional openness.
Others report intensity, anxiety, confusion, or prolonged aftereffects.
Some metabolize compounds differently.
Some may be more sensitive to shifts in serotonin, dopamine, or other neurotransmitter systems.

This section explores:

• 18 SNPs related to psychedelics
• Psychedelic response
• Neurotransmitter breakdown
• Psilocybin breakdown
• MDMA response and metabolism
• MDMA response
• LSD response and metabolism

This report does not encourage or recommend psychedelic use.

It provides genetic context for individuals and clinicians working in legal, clinical, or research-informed environments where these compounds may be discussed.

Ketamine Response

Metabolism. Antidepressant response. Provider-guided context.

Ketamine is increasingly discussed in clinical settings for mood-related care.

But response can vary.

Some people metabolize ketamine differently.
Some may experience stronger or weaker effects.
Some may have genetic patterns related to antidepressant response.

This section explores:

• 5 SNPs related to ketamine response
• Ketamine metabolism
• Ketamine antidepressant effects
• Genetic context for provider-guided discussions

This information is intended for educational use and clinician collaboration.

It does not determine whether ketamine is right for you. It helps inform the conversation.

Live-Updating Reports 

Your report evolves as research evolves.

As new peer-reviewed findings are added to our curated database, your panels update, without requiring re-testing.

Your genetics don’t change. The science does. And you continue to benefit from it.

The Bigger Picture

Your response is not random.

Your body’s response to medications, cannabis, ketamine, and psychedelics is shaped by many systems working together.

These include:

• drug metabolism pathways
• liver enzyme activity
• neurotransmitter signaling
• stress adaptation
• endocannabinoid sensitivity
• reward pathways
• cognition and perception
• detoxification and clearance
• mood regulation

The Medicine Match™ Genetic Test brings these systems together so you can better understand how your biology may influence response, sensitivity, metabolism, and risk.

Not so you can self-manage complex decisions.

So you can ask better questions. So you can share better context.  So you and your provider can make decisions with more information.

What This Test Is.....And What It Isn’t

This test is:

• educational
• research-informed
• designed for awareness
• intended to support better conversations with licensed healthcare providers
• useful for understanding genetic factors related to metabolism, response, and sensitivity

It is not:

• diagnostic
• predictive
• medical advice
• a recommendation to use cannabis, ketamine, psychedelics, or any medication
• a replacement for professional medical, psychiatric, or pharmaceutical guidance
• a guarantee of safety, effectiveness, or outcome

This information should always be reviewed with a qualified healthcare professional before making decisions about medications, cannabis, ketamine, psychedelics, or other compounds.

Why People Choose Medicine Match™

Because they have had confusing medication experiences.

Because they want to understand why certain compounds affect them differently.

Because they want to walk into provider conversations with better information.

Because cannabis, ketamine, and psychedelic response can be complex — and personal.

Because when something affects your mood, cognition, nervous system, or perception, you deserve more than guesswork.